Major histocompatibility complex class II expression and hemagglutinin subtype influence the infectivity of type A influenza virus for respiratory dendritic cells.
Identifieur interne : 000C37 ( Main/Exploration ); précédent : 000C36; suivant : 000C38Major histocompatibility complex class II expression and hemagglutinin subtype influence the infectivity of type A influenza virus for respiratory dendritic cells.
Auteurs : Kristian M. Hargadon [États-Unis] ; Haixia Zhou ; Randy A. Albrecht ; Haley A. Dodd ; Adolfo García-Sastre ; Thomas J. BracialeSource :
- Journal of virology [ 1098-5514 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Antigènes d'histocompatibilité de classe II (biosynthèse), Antigènes d'histocompatibilité de classe II (immunologie), Cellules dendritiques (immunologie), Cellules dendritiques (virologie), Expression des gènes, Femelle, Glycoprotéine hémagglutinine du virus influenza (), Glycoprotéine hémagglutinine du virus influenza (métabolisme), Souris, Souris de lignée BALB C, Virus de la grippe A (), Virus de la grippe A (croissance et développement).
- MESH :
- biosynthèse : Antigènes d'histocompatibilité de classe II.
- croissance et développement : Virus de la grippe A.
- immunologie : Antigènes d'histocompatibilité de classe II, Cellules dendritiques.
- métabolisme : Glycoprotéine hémagglutinine du virus influenza.
- virologie : Cellules dendritiques.
- Animaux, Expression des gènes, Femelle, Glycoprotéine hémagglutinine du virus influenza, Souris, Souris de lignée BALB C, Virus de la grippe A.
English descriptors
- KwdEn :
- Animals, Dendritic Cells (immunology), Dendritic Cells (virology), Female, Gene Expression, Hemagglutinin Glycoproteins, Influenza Virus (classification), Hemagglutinin Glycoproteins, Influenza Virus (metabolism), Histocompatibility Antigens Class II (biosynthesis), Histocompatibility Antigens Class II (immunology), Influenza A virus (classification), Influenza A virus (growth & development), Mice, Mice, Inbred BALB C.
- MESH :
- chemical , biosynthesis : Histocompatibility Antigens Class II.
- chemical , classification : Hemagglutinin Glycoproteins, Influenza Virus.
- classification : Influenza A virus.
- growth & development : Influenza A virus.
- immunology : Dendritic Cells, Histocompatibility Antigens Class II.
- chemical , metabolism : Hemagglutinin Glycoproteins, Influenza Virus.
- virology : Dendritic Cells.
- Animals, Female, Gene Expression, Mice, Mice, Inbred BALB C.
Abstract
Dendritic cells (DC) play a key role in antiviral immunity, functioning both as innate effector cells in early phases of the immune response and subsequently as antigen-presenting cells that activate the adaptive immune response. In the murine respiratory tract, there are several respiratory dendritic cell (RDC) subsets, including CD103(+) DC, CD11b(hi) DC, monocyte/macrophage DC, and plasmacytoid DC. However, little is known about the interaction between these tissue-resident RDC and viruses that are encountered during natural infection in the respiratory tract. Here, we show both in vitro and in vivo that the susceptibility of murine RDC to infection with type A influenza virus varies with the level of MHC class II expression by RDC and with the virus strain. Both CD103(+) and CD11b(hi) RDC, which express the highest basal level of major histocompatibility complex (MHC) class II, are highly susceptible to infection by type A influenza virus. However, efficient infection is restricted to type A influenza virus strains of the H2N2 subtype. Furthermore, enhanced infectivity by viruses of the H2N2 subtype is linked to expression of the I-E MHC class II locus product. These results suggest a potential novel role for MHC class II molecules in influenza virus infection and pathogenesis in the respiratory tract.
DOI: 10.1128/JVI.05830-11
PubMed: 21917972
Affiliations:
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Le document en format XML
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These results suggest a potential novel role for MHC class II molecules in influenza virus infection and pathogenesis in the respiratory tract.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Albrecht, Randy A" sort="Albrecht, Randy A" uniqKey="Albrecht R" first="Randy A" last="Albrecht">Randy A. Albrecht</name><name sortKey="Braciale, Thomas J" sort="Braciale, Thomas J" uniqKey="Braciale T" first="Thomas J" last="Braciale">Thomas J. Braciale</name><name sortKey="Dodd, Haley A" sort="Dodd, Haley A" uniqKey="Dodd H" first="Haley A" last="Dodd">Haley A. Dodd</name><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name><name sortKey="Zhou, Haixia" sort="Zhou, Haixia" uniqKey="Zhou H" first="Haixia" last="Zhou">Haixia Zhou</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Hargadon, Kristian M" sort="Hargadon, Kristian M" uniqKey="Hargadon K" first="Kristian M" last="Hargadon">Kristian M. Hargadon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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